Enhanced Mechanical and Cytocompatibility Properties of Novel 3D Printed Osteochondral Scaffolds

B. Holmes, J. Li, J. Lee, L. Zhang
The George Washington University, US

Keywords: stem cell, osteochondral, 3D printing, nanomaterial, carbon nanotubes

Summary:

As modern medicine advances, new and novel methodologies have been explored and developed in order to solve and improve current medical problems. One of the areas of investigation that has thus far proven to be very promising is tissue engineering. For many years, creating polymer scaffolds as a foundation for tissue growth has been one of the most popular approaches to tissue regeneration. The ultimate goal of a scaffold is to provide a framework that provides structural support for growing cells, as well as promoting cell growth and possible directing cell differentiation. In recent years research has been moving in the direction of seeding scaffolds with stem cells and attempting to direct their differentiation and proliferation to a desired tissue type. The objective of the current work is to create novel 3D printed osteochondral scaffolds with both excellent interfacial mechanical properties and biocompatibility for facilitating human bone marrow mesenchymal stem cell (MSC) differentiation. A series of novel 3D osteochondral computer aided models were designed including a homogenous cross-hatched structure, a bi-phasic structure consisting of a cross hatched pattern and an intersecting rings structure, and a biphasic key model.