Adjusting the MRI contrast by formation of defined SPIO clusters

J. Niehaus, S. Becker, H. Kloust, H. Weller
Center for Applied Nanotechnology, DE

Keywords: SPIO, iron oxide, cluster, MRI, MPI, contrast agent, continuous flow


Here we present our latest results in the development of optimized contrast agents for MRI and MPI measurements using iron oxide nanoparticles and the continuous flow phase transfer approach as described above. To yield a contrast agent with an increased MRI contrast we have developed a strategy to fill these capsules with a defined number of iron oxide particles. We will show the r2 relaxivity of clusters with single particle sizes ranging from 5 to 15 nm and an overall hydrodynamic diameter between 50 and 200 nm to determine the optimal cluster size for a maximum MRI contrast. In addition, we will show how this controlled clustering influences the performance of these particles in MPI studies.