Superparamagnetic Nanoparticles for Potential Application in Hyperthermia Treatment

C. Delaite, J. Winninger
Universtité de Haute Alsace, FR

Keywords: magemite, magnetic nanoparticles, nanocomposites, biomedical applications

Summary:

Hybrid organic-inorganic materials based on a magnetic core and a polymeric shell offer promising opportunities for industrial applications like data storage, inks and paints, but also for therapeutic applications including drug carriers, MRI contrast agents or magnetic hyperthermia mediators. In this last field, a lot of efforts are made for tailoring magnetic particles from the point of view of their size, magnetic properties, biocompatibility or colloidal stability. We focused on maghemite as the inorganic core and poly(ethylene oxide) to prepare materials combining the superparamagnetism and the inocuity of the iron oxide nanoparticles with the polyether biocompatibility. For in vivo biomedical applications, poly(ethylene oxide) is particularly interesting in order to produce a water stable dispersion with a long plasma half-life, due to the non-recognition of PEO coated surfaces by the mononuclear phagocyte system (opsonization process). An extension of this work to the grafting of hyperbranched polyglycidol on maghemite wll also be presented.