Spherical Nucleic Acids (SNAs) as Potent Gene Regulation and ImmunoModulatory Agents

D. Giljohann
AuraSense, US

Keywords: gold, nanotechnolgy, SNA

Summary:

Nucleic acid-based therapeutics (e.g., siRNA and antisense-DNA) hold promise as the next generation of targeted therapeutic agents, most notably allowing tailored regulation of the expression of proteins within cells. AuraSense Therapeutics' Spherical Nucleic Acid (SNA?) constructs, based upon nucleic acid-functionalized gold nanoparticles, will be discussed. We find that SNAs can be superior to alternative platforms based on multiple key success factors, such as high in vivo stability, deliverability, therapeutic targeting, and toxicity. How the SNA platform for nucleic acid-based therapeutics is applicable to numerous disease states, including inflammation and infectious disease, cancer, skin disorders and cardiovascular disease, will be discussed.