Targeting Cancer With A Novel Mesenchymal Stem Cell-Derived Nano-Delivery Platform

M. Machluf
Technion - Israel Institute of Technology, Israel, US

Keywords: cancer, drug delivery, cell membrane

Summary:

The ultimate goal in cancer drug- and gene delivery is a ‘magic-bullet’ that provides a versatile platform for site-specific targeting of multiple cancers, implemented in a clinically relevant and non-toxic design. We have designed a novel delivery platform, which is based on unique cell-derived nano-ghosts (NGs) produced from whole cell membranes of mesenchymal stem cells (MSCs). MSC are well known for their natural targeting of multiple cancers and hypo-immunogenicity. Encompassing MSC surface proteins and armed with their unique targeting capabilities, the MSC-NGs may be loaded with various drugs and nucleic acids and can be selectively targeted against multiple cancers. Such a universal targeting platform can meet the three major prerequisites for an ideal delivery system: biocompatibility, long circulation time, and selectivity. It also represents a much more clinically relevant approach than conventional delivery systems as it avoids the elaborate production and incorporation of targeting moieties into delivery vehicles. Demonstrating its efficacy on tumors, we will elaborate on its specificity and the wide range of applications, which such platform can clinically address. The NGs platform can also contribute to our understanding of cancer progression and can readily be extended to cancer imaging and diagnostics, paving the way to possible treatments of other diseases, manifested by the expression of unique targetable