DNA-based Nanostructures for Therapeutic Delivery in Cancer

P. Charoenphol, H. Bermudez
University of Massachusetts Amherst, US

Keywords: DNA, cancer, self-assembly

Summary:

In cancer therapy, the progressive resistance of conventional chemotherapeutic drugs remains one of the major problems, stressing the need for modular and multi-functional capabilities. Indeed, therapy focusing on a single gene or a single protein target has largely proven ineffective. We therefore propose a combination therapy strategy targeting the BCL-2 family, which are intimately involved in the regulation of several cancer apoptosis. Here, we develop DNA-based nanostructures for delivering dual bioactive motifs (AS1411 aptamer and BCL-2/-xL antisense) that simultaneously target BCL-2 proteins via different mechanisms of apoptosis action, aiming to achieve synergistic therapeutic benefits.