Oral administration of Liposomes Based on Biotin-Ceramide Conjugates in Cancer Therapy

L.-Y. Yu, S.-Y. Hung, C.-L. Lo
National Yang-Ming University, TW

Keywords: ceramide, liposomes, tumor therapy, oral drug delivery

Summary:

The oral drug delivery for cancer therapy is a challenge to overcome because drugs should stabilize in the stomach surroundings, drugs should be in safety in the gastrointestinal (GI) tract, and drugs could be able to uptake in the intestine and should arrive in targeted tumor. In this study, an oral liposome anticancer drug delivery system base on biotin-ceramide conjugates (BC-liposome) was developed to treat colon cancer.