Acrylated Block Copolymers for Mocuadhesive Micellar Delivery of Hydrophobic Drugs

T. Eshel-Green, H. Bianco-Peled
The Technion – Israel Institute of Technology, IL

Keywords: block copolymer, micelles, mucoadhesion

Summary:

Bioadhesion, the ability of a material to adhere to a biological substrate, was presented for the first time as a pharmacotechnical tool a few decades ago. Since then, bioadhesive polymers have received considerable attention for controlled drug delivery. In a recent study Davidovich-Pinhas confirmed the mucoadhesive properties of acrylated bulk polymers. In this work we evaluate the mucoadhesion properties of drug carrying micelles generated by acrylated amphiphilic polymers. This approach combines the advantages of mucoadhesive drug carriers with the well documented benefits of block copolymer micelles. Acrylated Pluronic® F127 was synthesized; the self-assembly process was investigated using Small Angle X-ray Scattering (SAXS) and Static Light Scattering (SLS). Interaction of the acrylated polymer with mucins type glycoproteins was examined in a series of tests, turbidity ,Isothermal Titration Calorimetry (ITC), rheology, SAXS and Dynamic Light Scattering (DLS). According to the results a covalent bond is formed between the acrylated micelles and the mucin which leads the way to a new and exciting set of nano vehicles decorated with acrylate end groups for the development of drug delivery systems. Further manipulations on those vehicles will include introduction of a hydrophobic drug into the micelle core and analysis of its release profile.