Nano”solutions” for Cancer

M. Kester
University of Virginia, US

Keywords: cancer, nanotechnology, calcium phosphosilicate

Summary:

Our team has previously reported that calcium phosphosilicate nanoparticles (CPSNPs) are nontoxic candidates for bioimaging and therapeutic drug delivery applications. The pH-dependent solubility profiles of CPSNPs make this class of nanoparticles especially useful for in vitro and in vivo delivery of fluoroprobes as well as chemotherapeutics. CPSNPs that encapsulate the near infra-red fluoroprobe, indocyanine green, have both diagnostic imaging and therapeutic efficacy. These “theranostic” attributes can be exploited to enhance photodynamic therapy (PDT), an alternative modality for cancer treatment. ICG-CPSNPs are both enhanced optical imaging agents as well as functionally stable photosensitizers for PDT. Data will be presented to demonstrate the theranostic potential of ICG-CPSNPs in multiple models of solid and non-solid tumors. Besides fluoroprobes and chemotherapeutics, CPSNPs can be formulated to encapsulate molecular-based therapies, such as siRNA. Data will also be presented demonstrating the utility of these non-cationic formulations in in vivo models of cancer.