Prostate-Specific Membrane Antigen Targeted Nanoparticles for Imaging and Therapy of Prostate Cancer

S. Ray
Johns Hopkins University, US

Keywords: cancer nanotechnology, PSMA target

Summary:

Prostate-specific membrane antigen (PSMA) is a transmembrane, type II glycoprotein that has abundant expression in primary prostate cancer and metastatic disease. Therefore, PSMA has been an attractive target for both targeted imaging and drug delivery. High binding affinity urea-based radio-halogenated, low-molecular-weight inhibitors of PSMA have recently been explored to image expression of PSMA in prostate tumor xenografts as well as in clinical studies. Those highly potent urea molecules can be used for decorating nanoparticle surface for guiding the nanoparticles to prostate cancer. Synthesis and characterization of different class of PSMA targeted nanoparticles will be presented.