Single Particle ICP-MS (SP-ICP-MS) a New Analytical Technique for Counting and Sizing Metal Based Nanomaterials: Theory and Application

C. Stephan
PerkinElmer Inc, CA

Keywords: SP-ICP-MS, particle sizing, counting, fate


Engineered Nanomaterials (ENMs) are synthesized by a manufacturing process that produces and controls ENMs to have at least one dimension in the range of 1 to 100nm in size. ENMs often possess different properties than their bulk counterparts of the same composition, making them of great interest to a broad spectrum of industrial and commercial applications. The widespread use and application of ENMs will inevitably lead to their release into the environment, which raises concern about their potential adverse effects on the ecosystems and, subsequently, human health. This talk goes over the theory of Single Particle ICP-MS (SP-ICP-MS), the importance of data acquisition speed, and describes its use in analyzing metal-based Nanoparticles. The single particle analysis technique allows for the differentiation between ionic and particulate signals, quantitation of each fraction, the measurement of particle concentration (particles / mL), determination of particle size and size distribution. In addition, it allows the user to explore particle agglomeration. SP-ICP-MS is a key analytical instrument in assessing the fate, behavior and distribution of (ENMs) in several types of matrices (environment, food, etc.).