Nanostructured Biomimetic Memristor Sensors Used for Therapeutic Monitoring of the Brain Cancer

E.T. Chen, J. Thornton, C. Ngatchou, S-H. Duh, P.T. Kissinger
Advanced Biomimetic Sensors, Inc., US

Keywords: nanobiomimetic memristor sensing, electric pulse treatment, 3D heat release mapping, ratio of action potential vs. resting potential


Current technology is not available to provide a portable, simple and accurate real-time monitoring and treatment of cancers simultaneously in an early stage at a clinical setting. Challenges for developing such a tool, include the need to develop an advanced sensing technology are paramount. Here we report a memristor sensor device (sensor #1) for timely monitoring and treatment of brain cancers at 5 cell/mL concentration. The purpose of this study is to determine the device’s capability to monitor the heat release at a 5 cell/mL concentration and compare these results with triple-negative (TNA) breast cancer results. The output of our device is a cancer cell heat release map in a 3D format which compares before and after treatment from three short pulses applied to the brain cancer cells in vitro based on a nanostructured memristor sensing technology with cross linked polymer membrane fabricated on gold chips under reagent-free condition as sensor #1 compared with a nanopore sensor #2 which has a selectivity for TNA cancer only. Our results shown the heat reduced by 60, 80 and 100% for sensor #1 compared with -40, 53 and 100% for sensor #2 after first, second and third pulse treatment, respectively