Discovery of novel polymeric platinum nanoparticles for targeted drug delivery

M.T. Proetto, S.B. Howell, N.C. Gianneschi
University of California San Diego, US

Keywords: cancer, platinum complexes, nanoparticles, drug delivery

Summary:

In this work, we seek to develop an entirely new method for the delivery of therapeutics in vivo. Our project investigates the inclusion of covalently bound, known anticancer platinum complexes into tumor-targeted self-assembled polymeric micellar nanoparticles. The primary innovation in the design of these micelles is the presence of a targeting moiety on the surface introduced via the polymerization chemistry we employ. By this approach, we aim for high selectivity and limited toxicity to normal cells. The second novel element is the covalent linkage of the metal complexes to the polymer, since they are monomers themselves and can therefore be directly polymerized providing a means for greater control of how much platinum is included in the particles. This feature ensures both optimized and controlled platinum loading of the nanoparticles in an unprecedented fashion. Such excellent control and ease of characterization should not be underestimated when considering a program seeking to optimize a nanoparticle system for in vivo use. The synthesis, characterization, in vitro drug release and cytotoxicity are part of our first set of studies to put this type of particles as a new platform for delivery systems of platinum-based drugs.