Electrically-Controlled Drug Release System to Assist Wound Healing

S. Zhu, J. Mbugua, M. Chase, J. Maskrod, J.H. Jung, T. Nicholson III, E. Fabrizio, R. Mercado
Crosslink, US

Keywords: electroactive polymer, controlled drug release

Summary:

The localized, controlled delivery of therapeutic agents is an attractive prospect for drugs with detrimental systemic effects at large dosages. An electronically-controlled drug delivery system (DDS) for the controlled release of negatively charged model compounds and drugs - such as sodium salicylate and ibuprofen, and positively charged drugs including lincomycin HCl, clindamycin HCl, and doxycycline, among others - has been demonstrated using polymeric electrodes based on biocompatible electrically conducting polymers (ECP). The DDS is easily prepared by the deposition of polymeric biocompatible ECP films via chemical-polymerization or electropolymerization of pyrrole or thiophenes and their derivatives. Several novel derivatives of pyrrole have been polymerized and their role as potential drug delivery electrodes investigated. Biocompatibility data for attractive polymers were acquired using three different mammalian cell lines. Loading of the drug molecules was achieved either by in situ polymerization of the monomers in the drug/monomer solution or by electrophoretic migration of the charged target drug from solution into the previously polymerized ECP films. Release was triggered by oxidation of the polymer for positively charged drugs or reduction of the polymer for negatively charged drugs.