A Novel High Yield Process for Gold Sulfide Nanoparticle Synthesis via Shifting Equilibrium of Self-Assembly Reaction

D. Patel, K. James, G. Zhang, A.M. Gobin
University of Louisville, US

Keywords: gold nanoparticles, synthesis

Summary:

This project is focused on the scale up of gold-gold sulfide (GGS) nanoparticles with desired near infrared peak (nIR) that can be used for therapeutic applications. By combining published methods for 1-step self-assembly of GGS nanoparticles and dialysis simultaneously (DiaSynth), the equilibrium of the reaction is shifted to favor the formation of nIR absorbing particles. This technique minimizes gold nanoparticles with 530 nm resonance (colloidal gold), resulting in populations of nanoparticles that require minimum further processing for use as a therapeutic agent.The DiaSynth method utilizes a shift in kinetics via removal of smaller ions during the reduction of gold & sulfur and assembly of the nIR absorbing particles using dialysis techniques.