Assessing the Manufacturing and Environmental Life Cycle of Engineered NanoParticles Using Inductively Coupled Plasma- Mass Spectroscopy (ICP-MS)

C. Stephan
PerkinElmer, CA

Keywords: ICP-MS, nanoparticles, environmental life cycle, single particle-ICP-MS

Summary:

The widespread use and application of ENMs will inevitably lead to their release into the environment, which raises concern about their potential adverse effects on the ecosystems and, subsequently, human health. To better understand ENMs in the environment, the following ENM characteristics will aid in this assessment: concentration, composition, particle size, shape, and other surface characteristics. This work describes the versatility of ICP-MS in analyzing Engineered Nanomaterials. In Standard Mode, an ICP-MS provides accurate composition and concentration measurements. In Single Particle Mode (SP-ICP-MS), it allows the differentiation between ionic and particulate signals, measures particle sizes (if shape is known), and explores agglomeration and size distribution. This versatile analytical instrument is suited for the determination of the elemental composition of engineered nanomaterials (ENMs), assessing the fate, behavior and distribution of MNs in several types of matrices (environment, food, etc.), evaluating the bioavailability and bioaccumulation of ENMs in the biota, and improving bio-labeling capabilities and advancements in the medical field.