Nanospray Dryer Employed in Nanoencapsulated Production

A.M. Oliveira, N.N.P. Cerize, K.L. Guimarães, J.G.R. Poco, A.S. Tunussi, D.C.S. Patto
Institute of Technological Research – IPT, BR

Keywords: nanospray dryer, drug delivery, vitamin, nanoencapsulation

Summary:

In the current study, nano and microparticle engineering of water soluble drugs was conducted using Nanospray Dryer B-190 (novel piezoelectric spray-drying approach). We explored the effect of the process on the solid state properties and release profiles of the engineered nanoparticles, by testing five different materials as encapsulating agent, gum arabic (GA), cashew gum (CG), alginate (AG), sodium carboxymethylcellulose (CMC) and eudragit RS100 (ED) as encapsulating matrix. Nanospray-drying studies were carried out with a hydrophilic model drug: vitamin B12. The particles obtained in were characterized related to particle size, morphology and kinetics of drug release. The viscosity of liquid stream showed a profound effect on the particle engineering and the obtained product yield. This novel spray-drying process proved to be efficient for nano and microparticle engineering of water soluble active substances.