Molecular Changes in Rat Brain Due to Air Nano Pollution

J.Y. Ljubimova, P.R. Gangalum, J. Portilla-Arias, R. Patil, B. Konda, M. Paff, J. Markman, S. Inoue, A. Espinoza, A. Chesnokova, M. Kleinman, E. Holler, K.L. Black
Cedars-Sinai Medical Center, US

Keywords: air nanopollution

Summary:

Air pollution has been found to cause neurodegeneration, deposition of heavy metals & beta amyloid plaques in the brain. Air pollution constitutes of nanopollutant of different sizes that can enter the system and cause diseases. To assess the effect of nanopolluants, we exposed rats to different particle sizes for 0.5, 1, 3 & 10 months, and analyzed brain tissues. Spectroscopy revealed accumulation of certain heavy metals in the rat brain. The uptake was highest at early exposure time. Microarray data showed changes in pituitary hormone genes & these changes were evaluated further by qPCR. We found significant alteration of pituitary hormones including glycoprotein hormones, prolactin and growth hormones in rats exposed to air pollution.