Three Wave in Disinfectant Science for Bacterial Inactivation

J. Liu, J. Dinn, W. Zhuang, H-C Zhou, S. Bashir
Texas A&M University-Kingsville, US

Keywords: bactericidal activity, nano-materials, green chemistry, metal-organic frameworks

Summary:

The significance of this work lies in the development of three-type of disinfectants to inactivate bacteria and for advancement of healthcare materials. This contributions center on: (a) Synthesis of series of nanoscaled disinfectants via bottom-up chemistry method with optimal fabrication parameters; (b) Characterization of textural, crystalline structure and elemental composition using microscopic and spectroscopic techniques; and (c) Evaluation of the potency of these materials as bacterial disinfectant. The originality of this work is two-fold: 1) fabrication of a nanocomposite and metal organic frameworks (MOFs), and 2) documented ultra-low minimal bactericidal concentration (MBC) against Gram-negative and Gram-positive microbe with high efficacy and persistence. A green chemistry method using natural product as reducing agents was employed to produce nanoscaled metal silver (Ag) and Ag-modified titania (TiO2). This approach allows for improving the environmental impact of hazardous waste. The second approach, a hydro-solvothermal, to prepare MOFs as disinfectants provides a new paradigm to mitigate bacterial contamination in food and water, which otherwise would pose a severe threat to the public health.