Boron Nitride Nanotubes functionalized with glucosamine as a potential novel carrier system for radioisotope and drug delivery

T.H. Ferreira, D.C. Ferreira Soares, L.M. Costa-Moreira, E. Martins Barros de Sousa
Centro de Desenvolvimento da Tecnologia Nuclear, BR

Keywords: boron nitride nanotubes, physicochemical and morphologically characterization, cytocompatibility investigation


In the present work, Boron nitride nanotubes (BNNTs) were synthesized and submitted to a functionalization process (coating) with glucosamine. The nanostructures were physicochemical and morphologically characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Raman Spectroscopy and Photon Correlation Spectroscopy (PCS). Furthermore, in vitro tests were conducted to evaluate the cytocompatibility of the nanostructures. The results revealed that nanotubes presented size, polydispersity index and Zeta potential adequate to applied in vivo studies. The cytocompatibility test were conducted in normal MRC-5 fibroblast lung cells, through MTT and DAPI assays. The results revealed, in tested concentrations (0.1; 10; 50; 100; 200 µ/mL), that BNNTs no presented a cytotoxic profile and negligible DNA changes. Considering the results obtained, the BNNTs showed adequate characteristic to be applied as novel carrier system for radioisotope and drug delivery.