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Indium Phosphide : Cadmium Free Quantum Dots for Cancer Imaging and Therapy

H. Chibli, L. Carlini, S. Park, N. Dimitrijevic, J.L. Nadeau
McGill University, CA

Keywords: InP, reactive oxygen species, cancer imaging, toxicity

Abstract:

We synthesised Indium phosphide (InP) quantum dots (QDs) with different shell layer. We demonstrate highly fluorescent labeling of cell lines after nonspecific endocytosis of the QD. With spin-trap electron paramagnetic resonance (EPR) spectroscopy and reporter assays we determined the nature of reactive oxygen species generated. The sulforodhamine B (SRB) viability assay indicates very low cytotoxicity in all cell line tested. These data indicate that straightforward methods of synthesis and solubilization result in InP QDs that are a viable alternative to cadmium-containing particles for biological applications.
 
 
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