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Synthesis and Characterization of Superparamagnetic Nanoparticles Coated with Carboxymethylated Cassava Starch for Drug Delivery System

K. Kasemwong, P. Nanta, W. Skolpap, U.R. Ruktanonchai
Nano Delivery System Laboratory, National Nanotechnology Center, TH

Keywords: 5-Aminosalicyclic acid, drug delivery, nanoparticles, superparamagnetic


Magnetic nanoparticles (MNPs) are increasingly being considered for a number of biomedical applications due to their inherent ultra fine size, biocompatibility and superparamagnetic properties. The functional properties of the MNPs can be tailored for specific biological functions, such as drug delivery, hyperthermia or magnetic targeting, magnetic resonance imaging (MRI), cell labeling and sorting, and immunoassays. The development of techniques that could selectively deliver drug molecules to the diseased site, without a concurrent increase in its level in healthy tissues, is currently one of the most active areas of cancer research. Thus from this study, the conjugate carboxymethylated cassava starch (CMC) / Superparamagnetic iron oxide (SPIO) nanoparticles were prepared by chemical reaction. Several parameters including the drug/polymer ratios in range of 1:14 were examined to optimize formulation. The size distribution and morphology of nanoparticles and in vitro release profile in phosphate buffer medium (pH 7.4) during 12 h were then investigated. The magnetic NPs prepared in this study were spherical with a relatively mono-dispersed size distribution. The conjugate CMS/SPIO nanoparticles were exhaustively studied as controlled-release systems for parenteral administration of a model drug 5-aminosalicyclic acid (mesalamine) and analyzed using various release kinetic studies.
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