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Assessment of comparative toxicity of nano- and microparticles of magnetite

B.A. Katsnelson, L.I. Privalova, T.D. Degtyareva, S.V. Kuzmin, M.P. Sutunkova, I.A. Minigalieva, E.P. Kireyeva, M.Y. Khodos, V.Y. Shur, E.V. Nikolaeva, I.E. Valamina, L.G. Tulakina, S.V. Pichugova, J.B. Beykin
Federal State Institution of Sciences Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, RU

Keywords: nanoparticles, magnetite, toxicity

Abstract:

Assessment of toxicity of 10 nm, 50 nm and 1 um Fe3O4 particles based on shift in the cell population of the broncho-alveolar lavage fluid after their intratracheal instillation into lungs of rats and on a set of indices of the organism’s status following repeated intaperitoneal injections showed that, in equal mass doses, nanoparticles were far more toxic than microparticles but induced a more active protective response of alveolar phagocytosis. The latter fact was established with optical, electronic, and SE atomic force microscopy.
 
 
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