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Label-free Raman Micro-Spectral Imaging of the Microenvironment of PANC-1 Spheroids

T. Chernenko, R. Shah, E. Zuser, M. Diem, M. Amiji
Northeastern University, US

Keywords: tumor model, drug delivery, imaging


Spheroids are 3D tumor models, which reflect diverse properties of the growing tumor. Due to its avascular microenvironment, initial tumor growth patterns as well as subsequent tumor-core biochemistry may be studied in depth, from which insight into tumor mass differentiation and organization may be deduced. A label-free and non-destructive imaging method recently gaining recognition is Raman micro-spectroscopy. We have thus utilized the instrumentation in synergy with mathematical data-unmixing algorithms, which paint a biochemical picture of the spheroid milieu. This non-invasive method of analysis will ultimately give rise to a more in-depth comprehension of the biochemical organization of the spheroid, render a better understanding of tumor growth and development, elucidate drug penetration patterns, and subsequently offer insight into its suppression.
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