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Effects of Chitosan and Nanoparticles on Survival of Schwann Cells and Dorsal Root Ganglion Neurons

J.C.K. Lai, W. Gao, S.W. Leung
Idaho State University, US

Keywords: Schwann cell, DRG neuron, chitosan, nanoparticle, biocompatible

Abstract:

We have systematically examined the effects of chitosan film or chitosan in combination with nanometal particles (nanogold or nanosilver particles) on the growth of Schwann cells (S16) and DRG neurons (50 B 11). Results of our on-going studies strongly suggest that chitosan and chitosan in combination with nanogold particles have no effects on the growth kinetics of Schwann cells. However, chitosan, and in particular, chitosan in combination with nanogold appeared to exert a small negative impact on the growth kinetics of DRG neurons. These findings suggest that chitosan and chitosan in combination with nanogold particles are more biocompatible with Schwann cells than with DRG neurons. On the other hand, chitosan in combination with nanosilver particles depressed the growth kinetics of both Schwann cells and DRG neurons. Thus, in the context of this type of application, nanosilver particles are much less biocompatible compared to nanogold particles. Consequently, our results suggest that chitosan film and chitosan in combination with nanogold particles may have significant potential to be further developed as suitable biocompatible materials for the fabrication of the ideal bioartificial nerve graft. Clearly, this is an interesting “tissue engineering challenge” for further investigation.
 
 
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