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Enhanced bioavailability of peptide YY using nanoporous silicon as a drug carrier

M. Kovalainen, J. Monkare, E. Makila, J. Salonen, V-P Lehto, K-H Herzig, K. Järvinen
University of Turku, FI

Keywords: bioavailability, sustained release, peptide, porous silicon


Biomedical applications of inorganic nanomaterials have been actively investigated during the last years. Porous silicon (PSi) is one of those new promising materials possessing several attractive properties. It is biodegradable and considered to be safe material for drug delivery, as has been investigated in vitro and in vivo. In addition, the pore size, specific surface area, pore volume, particle size and surface chemistry can all be easily tailored to obtain optimized functionality for desired purposes. In the present study, we have used nanoporous silicon microparticles as drug carriers to improve anti-obesity peptide YY3-36 (PYY) delivery. Three different surface chemistries were used and PYY plasma concentrations were analyzed after subcutaneous injections as a function of time. Sustained release of PYY was obtained with all the three surface chemistries, but with a thermally oxidized surface, 2.5-fold increase in bioavailability was observed. Terminal half-lives were also significantly changed from the initial 25 min of PYY solution up to 21 h indicating a strong influence of PSi carriers on the in vivo pharmacokinetics of PYY.
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