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Ceria Nanoparticles Reduce Disease Severity in a Mouse Model of Multiple Sclerosis

W.E. DeCoteau, A.Y. Estevez, S. Leo-Nyquist, K. Heckman, K. Reed, J.S. Erlichman
St. Lawrence University, US

Keywords: multiple sclerosis, cerium oxide, therapeutics


In the this study, 16 female SJL-EAE mice were treated with either vehicle or vehicle + 6 mg/kg cerium oxide nanoparticles (custom synthesized, 2.5 nm) 1 day prior to disease induction, the day of induction and days 7 and 14 post-induction. Testing included daily clinical scoring and three motor tests to evaluate hindlimb strength (rotarod), forelimb strength (hanging wire) and cerebellar function (balance beam). The acute phase of the disease peaked at day 14 post induction and remitted by day 20 post induction. Peak clinical scores were markedly reduced in ceria treated animals (2.4 ± 0.4 control vs 1.1 ± 0.4 treated) as were the motor deficits. Performance measures during the peak of the disease in ceria treated animals were no different than their pre-disease control measures. In contrast, vehicle treated animals had motor deficits that exceeded 50% of their pre-disease values. In separate studies, mass spectroscopy analysis of brain tissue from SJL mice treated with ceria showed significant deposition of ceria in the brains of control animals. Taken together, these data show that ceria nanoparticles are able to cross a patent BBB and can ameliorate the severity and motor deficits associated with EAE.
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