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Effects of Caffeic Acid Incorporated into Solid Lipid Nanoparticles in Cancer Cells

H.M. Kutlu, G. Guney, A. Iscan, L. Genc
Anadolu University, TR

Keywords: solid lipid nanoparticles, caffeic acid, TEM, confocal microscopy


Nanotechnology has great potential to make an important role in prevention of cancer, detection, diagnosis, imaging and treatment. Nanoparticles are at the cutting edge of the rapidly developing area of nanotechnology. Solid lipid nanoparticles (SLNs) have been introduced as an alternative drug carrier system. Some of the features of SLN include good tolerability, site-specific targeting, stability, high drug payload, controlled drug release. Caffeic acid (CA) is a widespread phenolic acid that occurs naturally in many agricultural products such as fruits, vegetables, wine, olive oil, and coffee. They are usually found as various simple derivatives including amides, ester, sugar ester and glycosides. Besides their well-known antioxidant activity CA inhibit certain enzyme activities such as lipoxygenases, cyclooxygenase, glutathione S-transferase, and xanthine oxidase. CA has been reported to has antitumor activity and anti-inflammatory properties and to inhibit HIV replication. We evaluated that caffeic acid loaded solid lipid nanoparticle interaction with H-ras transformed cell line, 5RP7. In this study, we aim to examine morphology, structural and ultrastructural changes of H-ras transformed cells which exposed to CA-SLNs find by using Transmission Electron Microscopy (TEM) and Confocal Microscopy. We found that CA -loaded nanoparticle formulations is significantly more effective and enhanced its efficacy against experimental tumors in the treatment of cancer as compared with free CA.
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