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Molar variation of water: alkoxy in the preparation of SiO2-DA materials and its effect on dopamine release from an implantable reservoir in the brain

T. Lopez, E. Ortiz, D. Esquivel, E. Garcia
National Institute of Neurology and Neurosurgery, MX

Keywords: Dopamine

Abstract:

In the present work we report the dopamine (DA) molecules stabilization in the network of nanostructured silica materials with the objective of using these as reservoirs of DA release in the brain. For this purpose we used the sol-gel process with controlled nitrogen atmosphere to stabilized successful dopamine molecules. Three different samples were prepared with a molar ratio alkoxy: water of 1:10, 1:20 and 1:40 respectively. These SiO2-DA result materials were characterized by FTIR and UV-VIS spectroscopy, Transmission Electronic Microscopy, N2 adsorption-desorption. A typical in-vitro drug release experiment was performed and monitored by HPL chromatograph. The result materials consist of nanoparticles aggregates generated mesopores with sizes ranging from 33 to 59 Å, depended on the amount of water used during the hydrolysis of TEOS and have a direct affect on dopamine release. From the Dopamine profiles an initial substantial increase in dopamine released, while in the second a decrease of concentration was observed. From the comparison between the textural properties and dopamine release, we determined that the most rapid release follows the next order: SiO2-DA-20H2O> SiO2-DA-40H2O> SiO2-DA-10H2O, nevertheless, it is clear that the interactions between SiOH and DA are also crucial for the release properties.
 
 
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