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Polymersome nanoreactors as artificial organelles (invited presentation)

J.C.M. van Hest, S.F.M. van Dongen, W.P.R. Verdurmen, R.J.R.W. Peters, R.J.M. Nolte, R. Brock
Radboud University Nijmegen, NL

Keywords: polymersomes, nanoreactors, cell-penetrating peptides, biocatalysis


Compartmentalisation is one of the techniques that cells adopt to enable a high level of control over (bio-)chemical processes, for instance the order in which enzymes react. In many cases, the compartment also serves to protect the cell from the action of its degrading contents, as is the case with lysosomes. It furthermore serves as a scaffold for the precise positional assembly of enzymes that work together in a multistep cascade reaction. In this paper we present two lines of research in which we exploit polymeric vesicles or polymersomes as nanoreactors. In one application we assemble three different enzymes in one nanoreactor in order to facilitate a cascade reaction. In the second line of investigation we introduce polymersomes in living cells as artificial organelles
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