TechConnectWorld 2011 Conference and Expo TechConnect World 2011 Nanotech 2011 Clean Technology 2011 Microtech 2011 Bio Nanotech 2011 TechConnect Summit and Expo 2011

Topical Sensory Nanoparticles for in vivo Biomarker Detection

J. Patrone, J. Benkoski, M. Patchan, X. Calderon-Colon, H. Le, J. Sample

Keywords: nanoparticle, sensor, peroxide, disease


We have recently developed a non-toxic, topically applied biosensor using solid lipid nanoparticles (SLN). This diagnostic platform is currently designed to continuously monitor hydrogen peroxide levels in skin. Overproduction of hydrogen peroxide is implicated in the development of many diseases, and may indicate early infection as well as exposure to toxins or radiation. We have characterized the efficacy and toxicity of these particles using several in vitro models. We envision further developing our SLNs as a platform for pain-free, topical diagnostics, tailored to the detection of specific biomarkers found in skin, including hormones, DNA, cytokines, and cholesterol. SLN detection may also be expanded to include detection of arbitrary biomolecules using a double antibody sandwich assay, analogous to the ELISA assay.
Sessions Monday Tuesday Wednesday Thursday Authors Keywords Affiliations Search

TechConnect World 2011 Nanotech 2011 Clean Technology 2011 Microtech 2011 BioNanotech 2011 TechConnect Summit 2011
2011 Events | Program | Speaker | Short Courses Sponsor Exhibit/Showcase Press Venue Register
Subscribe | Contact | Site Map
© Copyright 2010 TechConnect World. All Rights Reserved.