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Overcome the Doxorubicin Resistance by Multimodal Nanoparticles in Mice

P.-S. Lai, C.-Y. Hsu, H.-L. Lu, H.-P. Yu, W.-J. Syu, M.-J. Shieh
National Chung Hsing University, TW

Keywords: drug resistance, nanoparticles, photodynamic therapy


The efficacy of many chemotherapeutic agents is reduced in cells that have developed multiple drug resistance (MDR). To address this important problem, a biodegradable polymer was coupled to the photosensitizer and the resulting photosensitizer-nanoparticles were loaded with the chemotherapeutic agent doxorubicin. The combination of photosensitizer and chemotherapeutic agent had a synergistic action on a doxorubicin-resistant breast cancer MCF-7 cells. Clearly, the tumor regrowth delay was observed after administration of doxorubicin-loaded photosensitizer-nanoparticles plus light. This combination of photodynamic activity in a powerful nanocarrier loaded with the chemotherapeutic agent doxorubicin can be used to deliver two types of cancer therapy simultaneously and can overcome the drug resistance in vivo. Therefore, this innovative delivery system can act as a potential nanomedicine for both drug-sensitive and drug-resistant cancer therapy.
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