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Biomimetic Polyurethanes for Regenerative Medicine

G. Ciardelli, S. Sartori, P. Serafini, M. Boffito, A. Caporale, A. Silvestri, E. Bernardi, F. Boccafoschi
Politecnico di Torino, IT

Keywords: tissue engineering, polyurethanes, extracellular matrix mimics, phase separation


Degradable linear polyurethanes from non toxic building blocks were prepared. Bioactive peptides were incorporated in polyurethane chains, in order to create a synthetic equivalent of the Extracellular Matrix, able to mimic natural tissue. Both cell adhesive peptide (RGD sequences) and enzymatic proteolitically degradable peptides, containing the Ala-Ala sequence, were used as chain extender. Furthermore amino-derived diamines and cyclic diols were used as alternative chain extenders. Mechanical test showed the influence of the macrodiol and chain extender in mechanical properties. Biological test showed the effect of both functionalization and mechanical properties on cell adhesion.
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