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The effectiveness of a new nano-TiO2 biocide in inactivating methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans biofilms

C.E. Vergani, A.L. Machado, C.A. Zamperini, F.C. Picon, E. Longo
Univ Estadual Paulista - UNESP, BR

Keywords: titania, antimicrobial, MRSA, candida, biofilm


MRSA infections in hospitalized patients constitute a serious problem worldwide. A large portion of the MRSA infections in community hospitals is closely linked with other opportunistic pathogens, such as C. albicans. Both these microorganisms grow in highly resistant biofilms and it is estimated that biofilms are involved in most of human infections. Due to the outbreak of infectious diseases caused by these pathogens and the development of antibiotic resistance, researches are searching for new therapeutic agents against infections. TiO2 nanoparticles (TiO2NP) have been studied for various applications, including the inactivation of microbial cells. The present study evaluated the antimicrobial effectiveness of a TiO2NP solution against C. albicans and MRSA biofilms. A solution containing TiO2NP suspended in isopropanol only with anatase phase, with size between 3 and 5 nm, was prepared and used in the present study. The fungistatic and bacteriostatic effects against C. albicans and MRSA were evaluated. The results demonstrated that MRSA and C. albicans cells could be inactivated by the TiO2NP solution and that cells in biofilm were more resistant to killing than planktonic cells. The study indicates that the TiO2NP solution may be a potential candidate in developing new antimicrobial agents possessing both anti-candidal and anti-MRSA activity.
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