Cancer Nanotechnology

Cancer Nanotechnology

Symposium Co-Chairs

Mansoor M. AmijiMansoor M. Amiji
Distinguished Professor & Chair, Dept. of Pharmaceutical Sciences, Co-Director, Nanomedicine Education & Research Consortium
Northeastern University
Anil PatriAnil Patri
Deputy Director, Nanotechnology Characterization Laboratory
National Institutes of Health

Confirmed Invited Speakers

Peter L. ChoykeImaging the Lymphatic System with Nanomaterials
Peter L. Choyke
Senior Investigator and Chief of the Molecular Imaging Program, National Cancer Institute
Anu PuriLipid-based Phototriggerable Platforms for Improved Delivery of Anticancer Drugs
Anu Puri
Staff Scientist, Nanobiology Program, Center for Cancer Research, National Cancer Institute at Frederick, NIH
Justin HanesDrug and Gene Delivery to Mucosal Surfaces
Justin Hanes
Lewis J. Ort Professor & Director, The Center for Nanomedicine, Johns Hopkins School of Medicine
S. Rahima BenhabbourDevelopment of Lipid-based Nanocapsules of Novel Taxane Conjugates to Improve Treatment of Resistant and Metastatic Breast Cancer
S. Rahima Benhabbour
Research Assistant Professor, University of North Carolina at Chapel Hill
Jeff W.M. BulteMagnetoGVAX: Using Nanotechnology and MRI for Cancer Vaccine Development
Jeff W.M. Bulte
Professor of Radiology, Oncology, Biomedical Engineering, and Chemical & Biomolecular Engineering, Johns Hopkins University School of Medicine
Scott E. McNeilNanotechnology for Cancer Treatment: Lessons Learned from NCI’s Nanotechnology Characterization Lab (NCL)
Scott E. McNeil
Director, NCI’s Nanotechnology Characterization Lab (NCL)
Scott EliasofCerulean Pharma’s nanopharmaceuticals: From bench to bedside
Scott Eliasof
Vice President of Research, Cerulean Pharma Inc.
Jeff HrkachAccurins: Next Generation Targeted Cancer Therapeutics
Jeff Hrkach
Sr. Vice President, Technology, Research and Development, BIND Biosciences

Symposium Sessions

Monday May 13

11:00Cancer Nanotechology I
2:00Cancer Nanotechology II
Cancer Nanotechnology - Posters 4:00

Tuesday May 14

4:30Innovation Spotlights: Pharma & Medical Devices

Wednesday May 15

11:00Innovation Spotlights: Pharma & Biotech
4:00Innovation Spotlights: Medical Devices

Symposium Program

Monday May 13

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11:00Cancer Nanotechology IPotomac C
Session chair: Mansoor M. Amiji, Northeastern University, US
11:00MagnetoGVAX: Using Nanotechnology and MRI for Cancer Vaccine Development (invited presentation)
D. Kadayakkara, H.I. Levitsky, J.W.M. Bulte, Johns Hopkins University School of Medicine, US (bio)
11:30Imaging the Lymphatic System with Nanomaterials (invited presentation)
P.L. Choyke, National Cancer Institute, US (bio)
12:00Drug and Gene Delivery to Mucosal Surfaces (invited presentation)
J. Hanes, Johns Hopkins School of Medicine, US (bio)
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2:00Cancer Nanotechology IIPotomac C
Session chair: Mansoor M. Amiji, Northeastern University, US
2:00Accurins: Next Generation Targeted Cancer Therapeutics (invited presentation)
J. Hrkach, BIND Bioscience, US (bio)
2:30Lipid-based Phototriggerable Platforms for Improved Delivery of Anticancer Drugs (invited presentation)
A. Puri, Frederick National Lab for Cancer Research, US (bio)
3:00Cerulean Pharma’s nanopharmaceuticals: From bench to bedside (invited presentation)
S. Eliasof, Cerulean Pharma Inc., US (bio)
3:30Nanotechnology for Cancer Treatment: Lessons Learned from NCI’s Nanotechnology Characterization Lab (NCL) (invited presentation)
S.E. McNeil, NCI’s Nanotechnology Characterization Lab (NCL), US (bio)
4:00Development of Lipid-based Nanocapsules of Novel Taxane Conjugates to Improve Treatment of Resistant and Metastatic Breast Cancer (invited presentation)
S. Rahima Benhabbour, University of North Carolina at Chapel Hill, US (bio)
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Cancer Nanotechnology - Posters 4:00Expo Hall A
-Electrical detection of molecular surface receptor binding events in breast cancer cells
B.C. King, F. Khosravi, S.N. Rai, G. Kloecker, B. Panchapakesan, University of Louisville, US
-Bio-imaging of colorectal cancer models using a CK19-bioconjugated Quantum Dot Nanoprobe
M. Gazouli, N. Nikiteas, NP. Anagnou, N. Kelekis, E. Efstathopoulos, School of Medicine University of Athens, GR
-A Combined Optical Nanotechnology Approach for Colon Cancer Screening
N. Iftimia, A.K. Iyer, S. Ganta, A. Singh, M. Amiji, Physical Sciences, Inc., US
-Metastatic diagnosis of colon cancer by vertically aligned carbon nanotube based electromechanical biosensor
M. Abdolahad, H. Taghinejad, M. Taghinejad, M. Janmaleki, S. Mohajerzadeh, University of Tehran, IR
-Multispectral Optoacoustic Tomography (MSOT) Imaging of Heterogeneity within the Tumor Microenvironment
W.H.P. Driessen, N.C. Burton, J. Claussen, S. Morscher, T. Sardella, D. Razansky, V. Ntziachristos, iThera Medical, DE
-Highly sensitive detection of cancer biomarker EGFR by PicoTREC-SERS
L. Xiao, S. Harihar, Y. Wu, D.R. Welch, A. Zhou, Utah State University, US
-Superparamagnetic Iron Oxide Nanoparticles as Drug Delivery Vehicles
K. Vig, K. Casey, P.M. Tiwari, M. Miller, R. Samant, S.R. Singh, Alabama State University, US
-Lipopolymeric nanoparticles: platform technology for aerosolized combination chemotherapy
S. Kaur, R. Banerjee, Indian Institute of Technology Bombay, IN
-Synthesis of amphiphilic block copolymers to deliver HSP90 inhibitors for colorectal tumors
C-Y Lin, M-J Shieh, National Taiwan University, TW
-Enhancing the Cytotoxicity of Chemotherapeutics with Gold Nanoparticle Delivery
X. Zhang, J. Dostie, J. Teodoro, J. Nadeau, McGill University, CA
-Surface Properties of the Cancer Cell Lines by AFM
M. Tapia-Tapia, C. Lara Cruz, P. Damian-Matsumura, L. González Núñez, E. Ramon Gallegos and N. Batina, UAM-Iztapalapa, MX
-The Development of Stealth Poly-Ɛ-Caprolactone Nanoparticles For the Delivery of Bioactive Agents
O. Ogunwuyi, E. Akala, Howard University, US
-pH Responsive Polymeric Nanoparticles Fabricated by Dispersion Polymerization as a Platform for the Delivery of Anticancer Drugs
R. Puri, S. Berhe and E. Akala, Howard University, US
-Incorporation of Gold Nanoparticles into MCF-7 Breast Cancer Cells in the Presence of Estradiol
C. Lara-Cruz, L. González-Núñez, J.E. Jiménez Salazar, R.C. Lazzarini-Lechuga, E. Ramón-Gallegos, P. Damián-Matsumura and N. Batina, UAM-Iztapalapa, MX
-Magnetic Nanoparticle Hyperthermia for Treatment of Bladder Cancer: A Large Animal Feasibility Study
A. Mashal, M. Huisjen, K. McNerny, K. Frantz, M. Susedik, C. Adams, A. Updegrave, M. Ross, J. Tondu, D. McKenna, Actium Biosystems, US
-Cellular uptake and cytotoxic effect of broccoli phytochemical based gold nanoparticles (B-AuNPs): Enhanced cancer therapeutic efficacy
M. Khoobchandani, K. Katti, A. Zambre, K.V. Katti, University of Missouri, US
-GOLD NANOPARTICLES WITH SITE-TRIGGERED BIORECOGNITION FOR CANCER TARGETING
S. Salmaso, C. Brazzale, F. Mastrotto, G. Mantovani, C. Alexander, P. Caliceti, University of Padova, IT
-Covalent Funtionalization for Multi-walled Carbon Nanotube (f-MWCNT)-Folic Acid bound Bioconjugate
J.M. Ngoy, S.E. Iyuke, E.W. Neuse, C.S. Yah, University of the Witwatersrand, ZA
-Gold Nanorods Carrying Paclitaxel for Photothermal-Chemotherapy of Cancer
S. Bhana, X. Huang, University of Memphis, US

Tuesday May 14

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4:30Innovation Spotlights: Pharma & Medical DevicesPotomac 2
Session chair: Lynn Foster, BPT Pharma, US
4:30Language Analysis Tool Detects Cognitive Dysfunction for Early Alzheimer Diagnosis
A. Morrow, University of Minnesota, US
4:37Treating type 2 diabetes using menin inhibitors to regenerate insulin producing beta cells
F. Leu, Novapeutics LLC, US
4:44Integrated Continuous Manufacturing (ICM) of Pharmaceuticals
S. Mascia, CONTINUUS Pharmaceuticals, US
4:51Highly Sensitive Micron Scale Multiple Biomarker Biosensor
C. Yilmaz, Biolom, LLC, US
4:58Personal Health Expert
V. Shusterman, PinMed, US
5:05Flex Technology Inc
W. Krause, Flex Technology Inc, US
5:12Pharmaceutical technology of pharmaceutical composition and pharmacology treatment for enhancement of morphine analgesia and prevention of morphine tolerance
C. Laino, Biotechnology Institute, National University of La Rioja, AR
5:19Modular Biocompatible Materials for Medical Devices and Wound Healing Applications
S. Foster, Diazamed-CSU Ventures, US

Wednesday May 15

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11:00Innovation Spotlights: Pharma & BiotechPotomac 3
Session chair: Belen Martinez-Lopez, CaramelTech, MX, Reviewers: Roche, Sanofi, Merck, Jennifer Gottwald, WARF, US
11:00Roche - Strategic Innovation Interests
M. Wetzel, Roche, US
11:15Sanofi - Strategic Innovation Interests
S. Natesan, Sanofi, US (bio)
11:30Merck - Strategic Innovation Interests
S. Xanthoudakis, Merck, US (bio)
12:00Targeted Drug Delivery System/Keystone Nano
D. Fecko, Penn State Materials Research Institute, US
12:07Novel SiO2-based antioxidant compound with significantly extended life-time and activity
G. Sotiriou, ETH Zurich – ETH transfer (the Technology Transfer Office), CH
12:14Diabetes Control Algorithms and Clinical Trial Software
S. Juncal, UCSB Office of Technology & Industry Alliances, US
12:21Biodegradable Polymer for Biomedical Applications
L. Besemann, University of Minnesota, US
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4:00Innovation Spotlights: Medical DevicesPotomac 1
Session chair: Allen Dines, University of Wisconsin-Madison, US
4:00Fiberoptic Microneedle Device for Convection-Enhanced Thermochemotherapy of Malignant Glioma
C. Rylander, Virginia Tech Intellectual Properties, Inc., US
4:07CANCELED - Operation system of laparoscope using pneumatically driven robotic holder
M. Yamamoto, Japan Technology Group Inc., JP
4:14A high throughput one-step assay for circulating tumor cell detection in whole blood sample
Y. Zu, The Methodist Hospital, US
4:21CereScope™ - A Portable All-in-One Neurological Monitoring System
R. Kern, Optima Neuroscience, Inc., US
4:28Medipacs Mini-Infuser™
M. Banister, Medipacs.com, US
4:35Flat Panel X-ray Sources
M. Eaton, Stellarray, US

Special Symposium

Nanotechnology has the potential to have a revolutionary impact on cancer diagnosis and therapy. It is universally accepted that early detection of cancer is essential even before anatomic anomalies are visible. A major challenge in cancer diagnosis in the 21st century is to be able to determine the exact relationship between cancer biomarkers and the clinical pathology, as well as, to be able to non-invasively detect tumors at an early stage for maximum therapeutic benefit. For breast cancer, for instance, the goal of molecular imaging is to be able to accurately diagnose when the tumor mass has approximately 100-1000 cells, as opposed to the current techniques like mammography, which require more than a million cells for accurate clinical diagnosis.

In cancer therapy, targeting and localized delivery are the key challenges. To wage an effective war against cancer, we have to have the ability to selectively attack the cancer cells, while saving the normal tissue from excessive burdens of drug toxicity. However, because many anticancer drugs are designed to simply kill cancer cells, often in a semi-specific fashion, the distribution of anticancer drugs in healthy organs or tissues is especially undesirable due to the potential for severe side effects. Consequently, systemic application of these drugs often causes severe side effects in other tissues (e.g. bone marrow suppression, cardiomyopathy, neurotoxicity), which greatly limits the maximal allowable dose of the drug. In addition, rapid elimination and widespread distribution into non-targeted organs and tissues requires the administration of a drug in large quantities, which is often not economical and sometimes complicated due to non-specific toxicity. This vicious cycle of large doses and the concurrent toxicity is a major limitation of current cancer therapy. In many instances, it has been observed that the patient succumbs to the ill effects of the drug toxicity far earlier than the tumor burden.

This symposium will address the potential ways in which nanotechnology can address these challenges. Distinguished speakers will summarize the current state of the art and future barriers. Contributions are also solicited in the following topics.

  • Science and technologies for cancer diagnostic and imaging techniques using nanoparticles as reporter platforms and contrast enhancing agents;
  • Bionalaytical nanotechnology for detection of biomarkers
  • Nanoparticle platforms polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, magnetic nanoparticles, and self-assembling nanosystems;
  • Synthetic chemistry required to design and optimize new strategies for nanoparticle preparation and functionalization;
  • Therapeutic targeted and intra-cellular drug and gene delivery using nanocarriers;
  • Nanoparticles for delivery of electromagnetic energy for hyperthermia and thermal ablation of tumors;
  • Theoretical modeling of nanoparticle processes in biological and medical environments, and of drug and gene delivery;
  • Combination therapies (drug and energy delivery) using nanoparticles
  • Clinical diagnosis and therapy of prostate, breast, and liver cancer.

Topics & Application Areas

  • Cancer diagnostics
  • Cancer biomarkers
  • Cancer immunotherapeutics
  • Cancer ligands
  • Drug delivery
  • Other

Technical Abstract Submission

Please first review the information for authors as well as the abstract preparation guidelines.

 

Journal Submissions

Nanomedicine Journal

Nanomedicine: Nanotechnology, Biology and Medicine (Nanomedicine)

Nanomedicine NBM publishes articles on all issues related to nanomedicine, including the application of nanoscience and nanotechnology in biology and medicine.

Manuscripts must be directly or closely related to medicine (diagnosis, treatment, monitoring, prognosis and prevention of diseases) and supporting biology, especially understanding biologic mechanisms enabled by nanoscience, -engineering and -technology research, i.e.such as, research of man-made nanoscale objects, materials, and devices that improve medical procedures and outcome.

For consideration into the Nanomedicine: Nanotechnology, Biology and Medicine journal please select the “Submit to Nanomedicine: Nanotechnology, Biology and Medicine” button during the on-line submission procedure.

Nanoparticle Research

Journal of Nanoparticle Research

Selected Nanotech Proceedings papers will be reviewed and invited into a Special Issue of Journal of Nanoparticle Research. The journal disseminates knowledge of the physical, chemical and biological phenomena and processes in nanoscale structures.

For consideration into this Special Issue of Journal of Nanoparticle Research, please select the “Submit to Journal of Nanoparticle Research” button during the on-line submission procedure.

 

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