Development of novel nanoparticles for improved imaging, photo-thermotherapy, drug package, and targeting delivery.

Min Wu

Min Wu

Associate Professor

University of North Dakota

The Wu lab investigates molecular mechanisms of P. aeruginosa (PA) respiratory infection and its relationship with airway inflammation (asthma and chronic obstructive pulmonary disease, COPD). The lab focuses on fundamental mechanisms of biological processes: stem cell/progenitor differentiation, tissue repair, immunity, and homeostasis. Approaches include knockout mice, siRNA, miRNA, advanced microscopy and chromatin immunoprecipitation as well as clinical samples.

The lab studies how alveolar macrophages eradicate PA, particularly the mechanotransduction regulation of phagosome maturation. The lab has demonstrated that phagocytosis is linked to Lyn, Akt, and lipid rafts for clearance of the invading PA. Innate immunity (TLRs) may connect phagocytosis to autophagy processes. The long-term goal is to search for potential novel therapeutic strategies (herbs and gene delivery) and vaccines (e.g., attenuated bacterial strains). Another area of focus is to understand the role of base excision DNA repair (BER) in tissue injury and infection: whether environmental toxin/oxidant-induced genetic and epigenetic modifications are associated with pathogenesis of lung and neural-degenerative diseases. The lab also develops and analyzes novel silica nano-materials for cytotoxicity assessment and for applications in diagnostics, imaging, and therapeutic delivery in collaboration with Dr. J Zhao in the Chemistry Department.

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