Multi-functionalizations of Mesoporous Hollow Silica Nanospheres and Their HIFU Application

H. Chen, K. Zhang, X. Wang, Y. Chen, J. Shi
Shanghai Institute of Ceramics, CN

Keywords: mesoporous silica, multi-functionalization, HIFU


High intensity focused ultrasound (HIFU), as a representative non-invasive therapeutic mode, has attracted extensive attentions among biological and medical researchers. In this report, we focused on constructing novel mesoporous hollow silica nanospheres (MHSNs) as innovative and efficient theranostic/synergistic agents to explore them in HIFU application. On the basis of our former work on the mesoporous silica nanocapsule-based inorganic theranostic carrier, presenting an intensified ultrasound/MR imaging-guided HIFU cancer ablation, a novel temperature-responsive theranostic system is further synthesized and investigated, using L-menthol as phase-change medium. This temperature-responsive theranostic system enables the substantial co-entrapment of hydrophilic and hydrophobic drugs and their temperature-responsive release, and more importantly, can be used as both the ultrasound contrast agents and high intensity focused ultrasound (HIFU) therapeutic enhancement agents. Such multifunctional theranostic system demonstrated distinctively enhanced ultrasound imaging contrast and HIFU therapeutic efficacy owing to the controllable and unique phase-transition features of L-menthol under the mediation by HIFU irradiation.Therefore, it shows great potential in future cancer diagnosis and therapy, especially in overcoming multi-drug resistance and local controlled drug release in an on-demand fashion.