Induction of Tolerance for Therapy of Autoimmune Diseases Using Antigen-Linked Biodegradable PLG Nanoparticles – Mechanisms and Clinical Prospects

S. Miller, D. Getts, A. Martin, D. McCarthy, R. Terry, Z. Hunter, W. Yap, M. Getts, M. Pleiss, X. Luo, N. King, L. Shea
Northwestern University Medical School, US

Keywords: tolerance, autoimmunity, therapy, nanoparticles

Summary:

Ag-specific tolerance is the desired therapy for immune-mediated diseases. Our findings demonstrate the feasibility of using antigen-coupled biodegradable nanoparticles as a robust, novel, safe and cost-effective means for inducing antigen-specific therapy of MS and other (auto)immune-mediated diseases using an FDA-approved material, poly(lactide-co-glycolide) (PLG), which can be easily manufactured under GMP conditions.