Novel Lectin-Functionalized Nanoparticles and Nanorods for Specific Cancer Cells Targeting and Detection

V. Marangoni, J. Cancino, I.M.M. Paino, V. Zucolotto
University of São Paulo, BR

Keywords: nanomedicine, cancer diagnosis, nanotoxicology

Summary:

The development of nanomaterials complexed with specific biomolecules is crucial for the development of novel bioconjugates for application in Nanomedicine, as in the case of cancer biomarkers. Such nanocomplexes may exhibit excellent performance with high affinity and specificity toward cancer cell detection. However, the interpretation of the interactions between the biomolecules and the nanoscale-sized materials may be controversial, as well as the risks exhibited by these materials when in contact with living cells and tissues. This paper reports the processing of Au nanoparticles (AuNPs) and nanorods (Au NRD) stabilized with different biomaterials, including polyamidoamine (PAMAM) dendrimers and Lectins. The nanocomplexes exhibited excellent selectivity and affinity toward Hela and HepG2 cancer cells, acting as functionalized nanoprobes for optical diagnosis. The nanotoxicity exhibited by the nanocomplexes against healthy human cells will also be addressed.