A Specific Surface-coating Peptide for Rare Earth Nanomaterials

Y.J. Zhang, W. Zhou, L.P. Wen
University of Science and Technology of China, CN

Keywords: rare earth nanomaterials, phage display, peptides, cell interaction, biomedical applications

Summary:

The induction of autophagy on exposure of cells to a variety of nanoparticles represents both a safety concern and an application niche for engineered nanomaterials. Using phage display, we have discovered an 11-amino acid peptide that binds to rare earth nanomaterials with high affinity and forms a stable coating layer on the surface of the nanocrystals. The peptide efficiently reduces sedimentation of the nanocrystals and the interaction of nanocrystals with cells and surfaces, while the addition of a homing peptide enhances the interaction of nanocrystals with the target cells and organs. In this presentation I will present the latest development on utilizing this novel peptide to enable biomedical applications for rare earth nanomaterials and formation of rare earth-based composite nanomaterials.