Microwave irradiation and Click chemistry for highly efficient and chemoselective multivalent iron oxide nanoparticle surface modification

E. Guénin, E. Nehlig, P. Demay Drouard, F. Benyettou, L. Motte
Université Paris, FR

Keywords: magnetic nanoparticle, functionalization, click chemistry, microwave

Summary:

Magnetic nanoparticles (mNPs) are attractive candidates for numerous applications due to their unique properties. For all these applications mNPs surfaces must be tailored to improve biocompatibility properties or reduce aggregation but also to insert molecules on the particles with precise control of their architecture and surface density. So new methodologies for controlled and efficient functionalization of such materials are needed. In this contribution we will describe the use of various chemical approaches (microwave, click chemistry, photochemistry) for mNPs functionalization and present results of improve grafting rates (up to 40 fold increase). We moreover will propose a new nanoplateform allowing an orthogonal and chemoselective double functionalization.