Gold - iron oxide nanoparticles for photothermal cancer therapy

G.A. Sotiriou, F. Starsich and S.E. Pratsinis
ETH Zurich, CH

Keywords: nano particles, cancer therapy

Summary:

Plasmonic nanoparticles play an important role in biomedical applications today as they can serve as superior optically-stable bioimaging agents, be employed in biosensor devices for the early diagnosis of diseases, and also exhibit promising results to the in-vivo photothermal ablation of tumors because of their efficient near-IR light-to-heat conversion. Here, we show that by finely tuning the plasmonic Au nanoparticle coupling the optical absorption of those nanoparticles can be also finely controlled, broadening to it to the near-IR spectral region where human tissue has highest transparency. Hybrid plasmonic-superparamagnetic nanoparticles are encapsulated in-situ during their gas-phase synthesis by a nanothin, smooth silica coating with a precise control over the coating thickness. This fine control of the interparticle distance within each agglomerate enables such hybrid bionanoprobes to efficiently convert light-into-heat and facilitates their employment as efficient therapeutic agent in photothermal heat tumor ablation.