Fabrication of stable bio-compatible mesoporous silica and core-shell silica-magnetite nanoparticles for potential application in drug delivery

M.E. Sharifabad, T. Mercer, T. Sen
University of Central Lancashire, UK

Keywords: silica-magnetite, nanoparticles


Superparamagnetic iron oxide nanoparticles (SPIONs) have become increasingly attractive materials in the field of Nano / Nano-biotechnology due to their potential applications in heteogeneious catalysis [1, 2], nanomedicine such as drug delivery [3, 4], cell sorting / tissue engineering [5] and hyperthermia treatment of tumour in the presence of an external magnetic field [6]. Size, morphology and surface charge are three important parameters for drug loaded nanoparticles and their behavior in the blood stream when injected intravenously. Gupta et al [7] have reported that diameter of nanoparticles ranging from 10 to 100 nm are most effective for drug delivery because they can evade reticuloendothelial system (RES) and hence their circulation time in blood can be prolonged. One of the major problems of working on such nanoparticles is their propensity to aggregate. Fabrication of stable bio-compatible SPIONs of diameter 10-100 nm with specific surface charge and hydrophilicity is a challenge for drug delivery due to their multifunctional property. Recently we have reported [8] an interesting class of bio-compatible superparamagneic iron oxide nanoparticles (SPIONs) core and bio-compatible liposome shell for in-vitro drug loading and releasing study.