Tailored, Linear Release with Modular Nanosponge Delivery Systems

E. Harth, D. Stevens, G. Li
Vanderbilt University, US

Keywords: linear release, nanosolubilization of hydrophobic drugs

Summary:

The crosslinking process to form these nanopsonges is performed as a one pot-reaction and chemically guided self-assembly and crosslinking process leads to nanonetworks that are fully soluble in organics and behave like a macromolecule rather than a gel. The composition is fully adjustable and influences drug release rates as well as nanoscopic size dimensions. The fully degradable particles are semicrystalline at room temperature but amorphous at body temperature. The drug can be loaded into the particles in a postloading process in which hydrophobic chemotherapeutics become well-dispersed in aqueous solutions. The lack of solubility of chemotherapeutics is one of the major difficulties for administration and causes low bioavailability and efficacy. With this, drugs that have been unpopular because of their low solubility are being revitalized and drug discovery portfolios can be extended.