Synthesis and Characterization of Functionalized Magnetic Nanoparticles for Biomedical Applications

L.F. Wang, Y.L. Lo, J.H. Ke
Kaohsiung Medical University, TW

Keywords: magnetic nanoparticles, MRI contrast agents, drug delivery systems

Summary:

One-pot synthesized polyacrylic acid-modified iron oxide (PAAIO) was decorated with a polymer, which was served as a reservoir for a therapeutic agent or a fluorescent dye via chemical or physical approaches. PAAIO possess specific magnetic properties upon an exposed magnetic field, which endow them an attractive platform as a contrast agent for magnetic resonance imaging (MRI) and as a carrier for drug delivery systems. In this study, we are going to show some examples using surface-modified PAAIO in biomedical applications such as magnetofection,1 dual-modality nanoprobe, and theragnostics as a scheme shown below. Magnetofection is defined as the delivery of DNA,2 siRNA,3 or nucleic acids associated with magnetic nanoparticles to cells in the application of a magnetic field