Cerium oxide nanoparticles: an antioxidant nanostructure for regenerative medicine

S. Das, S. Chigurupati, J.F. McGinnis, M.P. Mattson, W. Self, S. Seal
University of Central Florida, US

Keywords: cerium oxide nanoparticles, regenerative medicine, scaffold Ceria

Summary:

Cerium oxide nanoparticles (CNPs) have shown promising results as antioxidant in biological system. CNPs have unique regenerative properties, owing to low reduction potential and co-existence of both Ce3+/Ce4+ ratio on the surface. Defects on the crystal lattice due to presence of Ce3+ play an important role in tuning redox activity of the CNPs. CNPs were shown to increase the life span of photoreceptors and neuron cells, which gives the rationale to explore CNPs for tissue engineering and regeneration fields. CNPs incorporated in the scaffold, either for soft or hard tissue regeneration, or direct application of CNPs in wound healing procedures have been reported. Free radical formation during the cellular growth hinders the cell differentiation, and CNPs could promote cell growth/tissue engineering by acting as an antioxidant. Herein, we present tissue regeneration and wound healing applications of CNPs.