Optimization of Dextrin Capped Magnetic Gold Nanoparticles

K. Chandler, H. Miller, E. Alocilja
Michigan State University, US

Keywords: magnetic, extraction, nnaoparticles

Summary:

The Nano-Biosensors Lab at Michigan State University has developed a unique approach for synthesizing magnetic gold nanoparticles using dextrin as a capping agent (Fe3O4@Aud). For this project, synthesis conditions were optimized based on their electrochemical response while maintaining stable, uniformly gold coated iron oxide cores. A systematic optimization of the synthesis procedure was completed by analyzing the effect of gold concentration, dextrin concentration, pH, temperature, number of iterations, and incubation time. Results showed that optimized parameters are as follows: 1.6 mg/ml gold chloride, 25 g/l dextrin, pH at 9, temperature at 60 oC, and 2 iterations allowed for even coating (Figure 1). Furthermore, dextrin capped particles produced stronger electrochemical response than citrate capped particles (Figure 2). This novel Fe3O4@Aud particle has the potential to be used as an extraction and detection tool for pathogenic cells in an electrochemical biosensor system. This characteristic is advantageous due to the potential for a more sensitive biosensor. The ease of detection of the dextrin capped magnetic gold particles, their low toxicity and their unique optical, chemical, and electrical properties make these novel particles a viable option for use in a biosensor system for the detection of harmful agents.