Extending the Dynamic Range of Single Particle Inductively Coupled Plasma Mass Spectrometry

K.E. Murphy, J. Liu, R.I. MacCuspie, M.R. Winchester
National Institute of Standards and Technology, US

Keywords: single particle ICP-MS, gold nanoparticles, characterization, size


The performance of a new analytical tool, inductively coupled plasma mass spectrometry operated in single particle mode (spICP-MS), is evaluated for the size characterization of gold nanoparticles (AuNPs) 60 nm to 200 nm in diameter. We show that under standard tune conditions (operating parameters adjusted to obtain maximum sensitivity for 197Au), a non-linear response is observed for AuNPs greater than 80 nm diameter. We investigate and compare different instrument conditions to reduce signal intensity. By operating the instrument at a low extraction lens voltage setting, size measurements of a mixture containing 60 nm, 80 nm, 100nm, and 200 nm AuNPs were successfully performed by spICP-MS.