Novel applications of poly(2-alkyl-2-oxzazoline)s

A. Fisher, M. Grossel, A. Tait, D. Davies, J. Schollick, D. Aarts
University of Southampton, UK

Keywords: thermoresponsive, polymer, thermogelling

Summary:

Poly(2-alkyl-2-oxazoline)s have attracted much attention in functional materials chemistry. In particular we are interested in using the thermoresponsive behaviour of poly(2-isopropy-2-oxazoline) for novel applications. We report here the development of two biologically compatible materials using poly(2-alkyl-2-oxazoline)s. We have synthesised poly(2-alkyl-2-oxazoline) coated surfaces and characterised these using two cell types for biological compatibility. All of these surfaces proved comparable to collagen coated glass. We have also synthesised the first reported poly(2-isopropyl-2-oxazoline) containing thermogelling polymer. This polymer reversibly gels above the lower critical solution temperature (LCST) of poly(2-isopropyl-2-oxazoline). It then reverts back to a liquid state below the LCST. We aim to use this as a material for stem cell growth which will facilitate simple recovery of the cells after incubation.