Nanometric analysis of the polysulfone membrane use for hemodialysis in the consecutive regime

G.M.C. Acosta, P.A. Avalos, M.A. Ramírez, M. Franco, G.H. Pérez,M.M. Cadena and N. Batina
UAM-Iztapalapa, MX

Keywords: hemodialysis, AFM, nano porosity


The hemodialytic treatment of patients with either acute or chronic renal failure has been improved by promoting biocompatibility in the use of new materials for hemodialysis membranes. Membrane surface morphology characteristics,qualitative and quantity evaluation of the cartridge quality, are important to predict and achieved better biocompatibility Low and high flux polysulfone membranes used in dialysis and ultra filtration have been widely studied, to understand the geometry and surface of the inner(nanometric) and outer (micrometric) membrane pores. Here surface changes of polysulfone cartridge membrane during different number of reuse trials: single trail, after 10th and 23th times of use, were studied. The morphology of the membrane surface was studied by atomic force microscopy (AFM)(the surface roughness analysis). The roughness of both inner and outer parts of membrane surface increases with numbers of reuse trails. Small and medium size pores were wiped out when increase number of use. The pore density decreases. The inner part of membrane shows some nanometric size deformation in forms of new openings and raptures. Results of AFM analysis show significant differences in the morphology of the polysulfone membrane at the nanometric level, during the consecutive use of membranes, not previously revealed.